Synthesis and in vitro cholesterol dissolution by 23- and 24-phosphonobile acids.
نویسندگان
چکیده
A new class of 23- and 24-phosphonobile acids have been synthesized from bile acid and their in vitro cholesterol-dissolving efficiency have been estimated. 24-Phosphonobile salts (PBSs) are slightly more efficient in solubilizing cholesterol than 23-PBSs and natural bile salts. The cholesterol solubilizing power is influenced by the structure of PBSs, and is considerably reduced with an increase in the bulk pH.
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ورودعنوان ژورنال:
- Steroids
دوره 70 10 شماره
صفحات -
تاریخ انتشار 2005